1. Nlmix: A Program for Maximum Likelihood Estimation of the Nonlinear
   Mixed Effects Model with a Smooth Random Effects Density.

   Nlmix is a program to estimate the fixed parameters of the nonlinear 
   mixed effects model and the density of the random effects jointly by 
   maximum likelihood.  The density of the random effects is assumed to 
   be smooth but is otherwise unrestricted.  The method uses a series 
   expansion that follows from the smoothness assumption to represent the 
   density and quadrature to compute the likelihood.  Simulation from 
   this representation is easy and may be used as an alternative to 
   quadrature.  Standard algorithms are used for optimization.  Empirical 
   Bayes estimates of random coefficients are obtained by computing 
   posterior modes.  

   Copyright (C) 1991 by Marie Davidian & A. Ronald Gallant. 

   Permission to use, copy, modify, and distribute this software and its 
   documentation for any purpose and without fee is hereby granted, provided 
   that the above copyright notice appear in all copies and that both that 
   copyright notice and this permission notice appear in supporting 
   documentation.  

   This software is provided "as is" without any expressed or implied 
   warranty.  


2. The nlmix source code is in directory pub/arg/nlmix/code.


3. The Nlmix Users Guide, in PostScript, is file nlmix.ps in directory 
   pub/arg/nlmix/guide.  
   
4. Nlmix uses the optimizer NPSOL.  We have been granted permission to 
   distribute NPSOL code in connection with distribution of SNP, a program for 
   nonparametric time series analysis.  As nlmix is layered on top of the SNP 
   code, which is included in the distribution of nlmix, we may distribute in 
   connection with nlmix.  See directory pub/arg/nlmix/npsol  There is no charge 
   but your institution will be required to honor the license agreement.


5. There is a machine dependent parameter eps in the files gaussq.f, mcarlo.f, 
   normalh.f, plot.f, post.f, and quad.f that are set for an IEEE machine,
   such as a Sun SparcStation2, and will need to be changed for machines
   that do not use IEEE floats.
 
6. nlmix.tar can be unpacked by using unzip on Microsoft Windows or
   tar -xf nlmix.tar on a Unix machine.